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Growth Factor Analog Peptide

IGF-1 LR3

An 83 acid synthetic analog of human insulin-like growth factor 1 with reduced binding protein affinity and extended half-life, studied for anabolic and tissue growth effects in preclinical research. Premium Research Peptide.

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$69.99
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Compound Information

Technical specifications

MOLECULAR PROFILE

What Is IGF-1 LR3?

Type:

Synthetic IGF-1 analog

CAS Number:

143045-27-6

Molecular Weight:

9,117.60 g/mol

Acids:

83

Sequence:

MFPAMPLSSLFVNGPRTLCG...

Formula:

C400H625N111O115S9

STRUCTURAL MODIFICATIONS

How It Differs from Native IGF-1

N-terminal extension

+13 amino acids (MFPAMPLSSLFVN)

Position 3 substitution

Glu → Arg

Total length

83 vs 70 acids

IGFBP affinity

Dramatically reduced

IGF-1R affinity

Retained

Sources & References

Peer-reviewed research

BIOCHEMICAL JOURNAL

Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats

1992 · DOI: 10.1042/bj2… · PMID: 1371669
Tomas FM, Knowles SE, Owens PC et al.

JOURNAL OF ENDOCRINOLOGY

Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained whe...

1996 · DOI: 10.1677/joe… · PMID: 8708565
Tomas FM, Lemmey AB, Read LC…

JOURNAL OF ENDOCRINOLOGY

IGF-binding proteins are multifunctional and act via IGF-dependent and -independent...

2002 · DOI: 10.1677/joe… · PMID: 12379487
Mohan S, Baylink DJ

AMERICAN JOURNAL OF PATHOLOGY

IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype

2011 · DOI: 10.1016/j.ajpa… · PMID: 21281823
von der Thüsen JH, Borensztajn KS,…

JOURNAL OF ENDOCRINOLOGY

Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IG...

1995 · DOI: 10.1677/joe… · PMID: 7561636
Conlon MA, Tomas FM, Owens PC et al.

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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