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Metabolic Peptide

5-GLow-1MQ

A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.

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$49.99
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Compound Information

Technical specifications

MOLECULAR PROFILE

What Is 5-Amino-1MQ?

Type:

Small molecule NNMT inhibitor

CAS Number:

42464-96-0

Molecular Weight:

159.21 g/mol (cation)

Salt Form:

286.11 g/mol (iodide salt)

Appearance:

Brown to reddish-brown solid

Formula:

C10H11N2+ (cation)

STORAGE REQUIREMENTS

Stability Information

Lyophilized (powder)

-20°C · stable 24+ months

Short-term storage

2-8°C · up to 30 days

Reconstituted

2-8°C · use within 7-14 days

Sources & References

Peer-reviewed research

JOURNAL OF MEDICINAL CHEMISTRY

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017 · DOI: 10.1021/acs.j… · PMID: 28548833
Neelakantan H, Wang HY, Vance V et…

BIOCHEMICAL PHARMACOLOGY

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase...

2018 · DOI: 10.1016/j.bcp… · PMID: 29155147
Neelakantan H, Vance V, Wetzel MD e…

BIOCHEMICAL PHARMACOLOGY

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and...

2019 · DOI: 10.1016/j.bcp… · PMID: 30753815
Neelakantan H, Brightwell CR, Graber…

SCIENTIFIC REPORTS

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes bod...

2021 · DOI: 10.1038/s415… · PMID: 33707534
Sampson CM, Dimet AL, Neelakantan…

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Development & Validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Applicati...

2021 · DOI: 10.1016/j.jpba… · PMID: 34304009
Awosemo O, Neelakantan H,…

JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in...

2021 · DOI: 10.1080/0144… · PMID: 33645410
Akar S, Duran T, Azzawri AA et al.

SCIENTIFIC REPORTS

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

2022 · DOI: 10.1038/s415… · PMID: 35013352
Dimet-Wiley A, Wu Q, Wiley JT et al.

DIABETES, OBESITY AND METABOLISM

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

2024 · DOI: 10.1111/do… · PMID: 39161060
Babula JJ, Bui D, Stevenson HL et al.

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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