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Cellular Peptide

Epithalon

Epitalon
Epithalone
AEDG Peptide
Ala-Glu-Asp-Gly
CAS: 307297-39-8

A 4 acid synthetic tetrapeptide modeled on pineal gland epithalamin that activates telomerase and modulates circadian gene expression in preclinical and early human studies. Premium Research Peptide.

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Compound Information

Technical specifications

MOLECULAR PROFILE

What Is Epithalon?

Type:

Synthetic tetrapeptide

CAS Number:

307297-39-8

Molecular Weight:

390.35 g/mol

Acids:

4 (tetrapeptide)

Sequence:

Ala-Glu-Asp-Gly (AEDG)

Formula:

C14H22N4O9

  • PubChem Database

STORAGE REQUIREMENTS

Stability Information

Protect from light
Avoid repeated freeze-thaw
Store in original sealed vial

Lyophilized (powder)

-20°C · up to 2 years

Reconstituted

2-8°C · up to 30 days

Sources & References

Peer-reviewed research

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties

2025 · DOI: 10.3390/ijm… · PMID: 40141333
Araj SK, Brzezik J, Mądra-Gackowska …

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

2003 · DOI: 10.1023/a10… · PMID: 12937682
Khavinson VK, Bondarev IE, Butyugov…

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells

2004 · DOI: 10.1023/b:bbe… · PMID: 15455129
Khavinson VKh, Bondarev IE, Butyugo…

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood...

2019 · DOI: 10.1007/s10517-019-0466…
Khavinson VKh, Pendina AA, Efimova…

MOLECULES

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis:...

2020 · DOI: 10.3390/mo… · PMID: 32019204
Khavinson V, Diomede F, Mironova E,…

MECHANISMS OF AGEING AND DEVELOPMENT

Effect of Epitalon on the Lifespan Increase in Drosophila melanogaster

2000
Khavinson VKh, Izmaylov DM,…

MECHANISMS OF AGEING AND DEVELOPMENT

Effect of Synthetic Thymic and Pineal Peptides on Biomarkers of Ageing, Survival and Spontaneous Tumour...

2001
Anisimov VN, Khavinson VKh, Mikhals…

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys

2001
Goncharova ND, Khavinson BK, Lapin…

INTERNATIONAL JOURNAL OF CANCER

Inhibitory Effect of the Peptide Epitalon on the Development of Spontaneous Mammary Tumors in...

2002 · PMID: 12209581
Anisimov VN, Khavinson VKH,…

JOURNAL OF RESTORATIVE MEDICINE

Improving Biological Age, Telomere Length, and Cognition: A Case Study

2024
Published case report

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture

2012
Khavinson VK, Linkova NS, Kvetnoy IM,…

ADVANCES IN GERONTOLOGY

AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts

2022
Gutop EO, Linkova NS, Kozhevnikova…

  • IMPORTANT RESEARCH NOTICE

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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