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Cognitive & Neuroprotective Peptide

SEMAX

ACTH (4-10)
ACTH (4-7)-Pro-Gly-Pro
MEHFPGP
Met-Glu-His-Phe-Pro-Gly-Pro
CAS: 80714-61-0

A 7-acid synthetic heptapeptide analog of ACTH (4-10) that upregulates BDNF expression and modulates the TrkB signaling pathway, studied for cognitive enhancement and neuroprotection in clinical research. Premium Research Peptide.

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$29.99
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Compound Information

Technical specifications

MOLECULAR PROFILE

What Is Semax?

Synthetic heptapeptide analog of ACTH (4-10) with C-terminal Pro-Gly-Pro extension for enhanced stability

Heptapeptide
ACTH Analog

Type:

Synthetic heptapeptide

CAS Number:

80714-61-0

Molecular Formula:

C37H51N9O10S

Molecular Weight:

813.9 g/mol

Acids:

7 residues

Sequence:

Met-Glu-His-Phe-Pro-Gly-Pro

  • PubChem Database

STORAGE REQUIREMENTS

Stability Information

Handle with care to maintain potency

Light sensitive
Temperature sensitive

Lyophilized (powder)

-20°C · protect from light

Reconstituted

2-8°C · use within 4 weeks

Nasal spray (0.15%)

2-8°C · 30 days after opening

DEVELOPMENT STATUS

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Developer:

Russian Academy of Sciences

Approval:

Russia (1990s)

Indications:

Stroke, cognitive impairment

Formulations:

0.1% and 1% nasal spray

US Status:

Not FDA-approved

Related Peptide:

Selank (tuftsin analog)

Sources & References

Peer-reviewed research

BRAIN RESEARCH

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat...

2006 · DOI: 10.1016/j.bra… · PMID: 16996037
Dolotov OV, Karpenko EA, Inozemtsev…

BMC GENOMICS

The peptide semax affects the expression of genes related to the immune and vascular systems in rat...

2014 · DOI: 10.1186/1471-… · PMID: 24661656
Medvedeva EV, Dmitrieva VG…

ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S.S. KORSAKOVA

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

2018 · PMID: 29798983

JOURNAL OF MOLECULAR NEUROSCIENCE

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus,...

2019 · PMID: 31625062
Kozlovskii II, Andreeva LA, Myasoedov…

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

2020 · PMID: 32575851

ALZHEIMER’S DRUG DISCOVERY FOUNDATION

Semax - Cognitive Vitality For Researchers

PUBCHEM DATABASE

Semax - Compound Summary (CID 981102)

  • IMPORTANT RESEARCH NOTICE

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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